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新年夜，急診室突然沖進了一個服用過量安眠藥的女孩，杜梅在救治過程中陰差陽錯的與方言和其哥們潘佑軍相識。杜梅的好友賈玲是一名空姐，與方言同在航空公司工作。于是，這四個單身男女成為了朋友。
剛剛與男友分手的賈玲與方言一見如故，兩人若即若離的周旋于情感游戲中，但很快賈玲發現杜梅對方言也懷有一種特殊的感情，漸漸的，三人之間的關系微妙起來，產生了一種說不清理還亂的情感暗涌。除夕夜，方言面對寂寞無助的杜梅第一次產生了強烈的愛意，最終，賈玲選擇退出，方言和杜梅走到了一起，兩人在經歷甜蜜的戀愛后，在大家的祝福下結婚了，有了一個屬于自己的家。
在婚后的共同生活中，杜梅和方言卻慢慢發現彼此對愛的認知不盡相同，面對杜梅奮不顧身的投身于愛情中，方言無所適從，他越來越發現自己無法承擔情感的重負，只能選擇逃避，開始，兩人每一次爭吵過后又會試圖彌補，但漸漸的，這樣的生活令他們越來越麻木，越來越冷漠。在冷酷的現實面前，杜梅無法面對，只能拼命的維系，她開始猜疑方言，而這樣恰好傷害了自己，也傷害了方言，終于，兩人在經過一次大吵之后，杜梅把方言捆綁在家中，用刀逼迫方言對自己說 “我愛你”，方言忍無可忍只得破窗而出，兩人在徹底失望中選擇了離婚。離婚那天，兩人形同陌路，各奔一方，至此沒有再聯系。
離婚后，方言辭了職，和潘佑軍一起離開北京去成都做生意，而杜梅則發現自己懷孕了，就在她決定要留下孩子的時候，卻因一次意外而流產了，很快，痛苦的杜梅發生了一次醫療事故被醫院開除，絕望中杜梅選擇了不告而別。
一年后，方言重新回到了北京，此時，他才從賈玲口中知道了杜梅的真實境遇，懷著深深的內疚，方言費勁周折找到了杜梅，把她接到了自己的家，此后，兩人以朋友的身份再次生活在同一屋檐下，此時，曾經追求過杜梅的高中同學錢康和方言在成都認識的女孩韓麗婷各自對他們展開了情感攻勢，在復雜的情感關系中，杜梅和方言卻越來越發現他們難以忘懷彼此，兩人依舊深深相愛，深深眷戀，最終，他們的情感也打動了錢康和韓麗婷，兩人主動提出希望杜梅和方言復合。
就在杜梅和方言反思婚姻，反思情感，決定重新開始之時，方言卻發現自己患上了一種奇怪的病癥，他偷偷到醫院去檢查，醫生告訴方言他的病叫“重癥肌無力”，目前還沒有特別好的根治辦法，不忍拖累杜梅的方言在無奈下只得找到賈玲，希望她能幫助自己，矛盾中，賈玲因為方言對杜梅的愛而答應了他的請求，兩人痛苦的在杜梅面前演出了一幕移情別戀，面對此景，杜梅深受刺激獨自離開，兩人再次分道揚鑣。
對所有人隱瞞了病情的方言悄然離去，不久，杜梅從賈玲口中知道了真實的情況，她不顧一切尋找方言，最終在兩人相愛時曾經約定過的海邊找到了已經病情惡化的方言，此刻，方言已經處于絕望，看著自己一天天的衰弱下去，他選擇自我了斷，但卻被杜梅阻止，她告訴方言無論如何不要放棄，最終，在杜梅愛情的力量感召下，方言決定和病魔抗爭，兩人回到北京，參加了錢康和韓麗婷的婚禮，他們面對一對新人彼此相擁，傾聽著神圣的結婚誓言，此時此刻，兩人百感交集，相互凝望，良久，他們對彼此綻放了會心的微笑。
杜梅和方言一起登上了去深圳的航班，為了對抗病魔他們并肩做著最后的努力，飛機轟鳴著穿過了云層，耀眼的太陽就在前方……
